601 East Jefferson Street represents a unique hospitality property located in the heart of Louisville's downtown corridor. Positioned within the dynamic Phoenix Hill neighborhood, the site combines historic character with high-visibility frontage along a well-trafficked urban street. Built in 1890, this structure spans approximately 15,804 square feet and sits on 0.40 acres, offering adaptability for boutique hotels, extended-stay lodging, or potential redevelopment. The property benefits from proximity to major downtown anchors, including business districts, cultural institutions, and entertainment destinations along East Market Street. It is easily accessible via I-65 and I-64 and is less than 15 minutes from Louisville Muhammad Ali International Airport, ensuring strong connectivity for regional and national visitors. Surrounding amenities include an eclectic mix of restaurants, residential developments, and creative workspaces, positioning the asset within a growing market that appeals to both leisure and business travelers. This opportunity delivers scale and location advantages for investors targeting Louisville’s thriving urban core.