572 S Salina Street presents a prime office leasing opportunity for professional or medical tenants seeking high-visibility space in the heart of Downtown Syracuse. This ±19,794 square foot, two-story building sits prominently at the intersection of South Salina Street—the city’s main commercial corridor—and West Adams Street, placing it in close proximity to Syracuse’s key business, healthcare, and transit anchors. Configured for multi-tenant occupancy, the building offers a mix of professional office suites and medical-ready space, with flexible layouts that support a wide range of uses. A former VA Clinic previously occupied the second floor, which includes infrastructure such as exam rooms, private offices, cubicle zones, and conference areas. The first-floor suite includes open and private office layouts ideal for legal, financial, or consulting uses. Both floors offer customizable build-out options based on tenant requirements. Amenities include a dramatic two-story glass atrium, abundant natural light, 3,000± SF of basement storage, and 50+ surface parking spaces—a rarity in downtown Syracuse. A landscaped courtyard with patio seating provides added tenant value. The property benefits from excellent visibility and access, fronting South Salina, South Clinton, and West Adams Streets, and is directly across from the Centro Regional Transit Hub. Located just minutes from I-81, I-690, and major employers including Syracuse University and local hospitals, 572 S Salina Street offers tenants an unbeatable mix of visibility, accessibility, and convenience. Whether you're seeking a standalone headquarters, flexible professional office, or medical clinic, 572 S Salina Street offers unmatched potential in one of Syracuse’s most strategic downtown locations.