572 S Salina Street presents a prime office leasing opportunity for professional or medical tenants seeking high-visibility space in the heart of Downtown Syracuse. This ±19,794-square-foot, two-story building sits prominently at the intersection of South Salina Street, the city's main commercial corridor, and West Adams Street, close to Syracuse's key business, healthcare, and transit anchors. Configured for multi-tenant occupancy, the building offers a mix of professional office suites and medical-ready space, with flexible layouts that support a wide range of uses. The first-floor suite includes open and private office layouts ideal for legal, financial, or consulting uses. Customizable build-out options are available to first-floor tenants, based on specified requirements. Amenities include a dramatic two-story glass atrium, abundant natural light, approximately 3,000 square feet of basement storage, and 50+ surface parking spaces, a rarity in downtown Syracuse. A landscaped courtyard with patio seating provides added tenant value. The property benefits from excellent visibility and access, fronting South Salina, South Clinton, and West Adams Streets, and is directly across from the Centro Regional Transit Hub. Located just minutes from Interstates 81 and 690, and major employers, including Syracuse University and local hospitals, 572 S Salina Street provides unbeatable visibility, accessibility, and convenience. Whether seeking flexible professional office or medical clinic space, 572 S Salina Street offers unmatched potential in one of Syracuse's most strategic downtown locations.