572 S Salina Street offers a prime investment or owner/user opportunity for a centrally located, high-visibility professional and medical office asset in the heart of Downtown Syracuse. This 19,794-square-foot, two-story building sits at the intersection of South Salina Street, Syracuse's Main Street, and West Adams Street, placing it at the epicenter of the city's business, healthcare, and transit corridors. Configured for multi-tenant use, the property features a mix of general office suites and medical-ready space, with flexible floor plans for a wide range of professional services or clinical uses. A VA Clinic previously occupied the second floor, offering a medical-office infrastructure complete with exam rooms, private offices, cubicle areas, and conference rooms. The first floor includes open and private office layouts suited for legal, financial, and consulting firms. Both levels support customizable buildouts to accommodate a variety of user needs. 572 S Salina Street features a dramatic two-story glass atrium, continuous window lines for natural light, an additional 3,000 square feet of basement storage space, and over 50 surface parking spaces, a rare amenity in the downtown core. An outdoor courtyard with patio seating provides space for informal meetings and employee use. The property is directly across from the Centro Regional Transportation Center and has direct access to South Salina, South Clinton, and West Adams Streets. 572 S Salina Street enjoys excellent visibility and accessibility near Interstates 81 and 690. Major employers, residential developments, Syracuse University, and St. Joseph's and Crouse Hospitals are just a mile away. Whether repositioned as a headquarters, professional office hub, or healthcare facility, 572 S Salina Street represents a strategic acquisition opportunity in one of Syracuse's most connected and dynamic downtown locations.