572 S Salina Street presents prime professional and medical office space in the heart of Downtown Syracuse. This two-story, 19,794-square-foot multi-tenant building features professional office suites and a medical office-ready environment with flexible configurations. Positioned on a high-visibility corner lot at the intersection of South Salina Street, often referred to as the city's Main Street, and West Adams Street, the property sits at the center of commerce, commuting, and community life. Inside, tenants benefit from a two-story glass atrium, continuous window lines for natural light, and ample surface parking with over 50 dedicated spaces included in the lease. The property also features an outdoor courtyard with patio seating for employee breaks or casual meetings and 3,000 square feet of basement storage, included at no extra cost. The first-floor space is configured for general office use with a combination of private offices and cubicles, which is ideal for law firms, consultants, or professional services. The entire second floor, formerly home to a VA Clinic, is designed with medical tenants in mind, featuring exam rooms, private offices, cubicle space, and conference rooms. Both floors offer flexible build-out options to meet tenant-specific needs. 572 S Salina Street is directly across from the city's central bus station, Centro Regional Transportation Center, offering unmatched accessibility. Direct access points from South Salina, South Clinton, and West Adams Streets, plus immediate proximity to Interstates 690 and 81, provide seamless connectivity. The area's largest employers, residential communities, and downtown dining, shopping, and entertainment are within walking distance, and Syracuse University, St. Joseph's Hospital, and Crouse Hospital are just a mile away. Don't miss this unmatched opportunity to secure premier office or medical space in one of Syracuse's most connected and visible downtown locations.