5421 Thekla Avenue represents an increasingly rare opportunity to acquire a sizable educational campus within the St. Louis urban core, offering meaningful flexibility for institutional operators, specialty users, or developers seeking large, adaptable structures with strong regional access. The campus, formerly occupied by Confluence Aspire Academy, spans two buildings across a generous 4.84-acre site and was comprehensively renovated in 2007, ensuring a functional and modernized environment for a wide range of future uses. Its location near Interstate 70 allows for efficient citywide connectivity while maintaining accessibility for surrounding residential neighborhoods. The interior layout of the campus features multiple classroom wings, technology and art rooms, science suites, administrative offices, staff work areas, specialized learning rooms, and extensive restroom facilities that support high-capacity daily use. Both buildings include lower, main, and upper levels organized for structured circulation, and the site includes nearly eighty dedicated surface parking spaces to accommodate staff, visitors, and programmatic needs. Amenities such as a gymnasium, cafeteria, stage area, and multipurpose rooms amplify the property’s suitability for educational uses or adaptation into community-oriented programming. For adaptive reuse, the campus provides compelling redevelopment potential. Large floor plates, compartmentalized learning areas, and wide corridors lend themselves to creative reuse for residential concepts, social services, nonprofit operations, office configurations, or hybrid community space. The surrounding area includes major cemeteries, stable residential blocks, and established community institutions, creating a consistent activity base and steady traffic patterns. Offered at $5.6 million, the property delivers immediate utility for mission-driven organizations or long-term upside for groups seeking a conversion opportunity with significant structural scale. Its combination of acreage, renovated facilities, and flexible layout positions 5421 Thekla Avenue as a distinctive asset within the St. Louis market.