Positioned along the established Grissom Road commercial corridor, 5421 Grissom Rd offers approximately 2,400 square feet of versatile commercial space on a 0.48-acre site. The property features a floor-to-ceiling glass storefront providing strong street visibility and abundant natural light, complemented by an open floor plan suitable for retail, professional office, or service-oriented users. The interior includes a private office, separate men’s and women’s restrooms, storage space, and air conditioning. Additional property features include pylon and building signage opportunities, a fenced lot, security system, 24-hour access, and proximity to public transportation. With C-2 zoning, prominent Grissom Road exposure, and a flexible layout, the property provides a well-positioned leasing opportunity for businesses seeking visibility, accessibility, and functional commercial space in San Antonio.