0.66 Acre site in premier location in Glen Carbon IL – one of the market’s most desirable municipalities. The site is zoned General Commercial and currently houses a 1,008 square foot single family home. 4501 S State Route 159 offers an exceptional opportunity along one of the Metro East’s most heavily traveled commercial corridors. Situated in the heart of Glen Carbon, this property benefits from outstanding visibility and daily traffic counts exceeding 30,000 vehicles, making it an ideal site for retail, office, or service-based development. The property is surrounded by strong commercial activity, including national retailers, restaurants, and professional offices, while also being just minutes from I-270, providing direct access to the greater St. Louis region. Its location in Glen Carbon—consistently ranked as one of the area’s most desirable and fastest-growing communities—ensures a stable customer base supported by strong demographics, excellent schools, and steady residential growth. With high visibility, easy accessibility, and a thriving business environment, 4501 S State Route 159 presents a premier opportunity for investors, developers, or owner-users seeking a strong position in the Metro East market.