4501 South Western offers four full-floor loft office suites for lease in a historic brick-and-timber building located in Chicago’s Back of the Yards neighborhood. Each suite features expansive 34,364 SF floorplates with exposed brick, timber beams, and high ceilings, delivering a unique aesthetic ideal for creative office, light manufacturing, or flex users. Suite 1 on the first floor includes 40,388 RSF and features staging, receiving, and dock areas, while upper floors offer a mix of offices, conference rooms, break areas, and specialized rooms such as spray booths and server rooms. Tenants benefit from 55 on-site parking spaces and exceptional access to I-55, I-90/94, and CTA transit, including the Orange Line just 0.5 miles away. The building’s location in a revitalizing corridor supports operational efficiency and workforce accessibility, with proximity to Midway Airport (3.9 miles) and the Chicago Loop (7.1 miles). Lease rates are subject to offer, and all suites are available immediately. This is a prime opportunity for businesses seeking adaptable, character-rich space in a well-connected, emerging district.