4266 Main Street offers a rare opportunity to secure a premier restaurant space in the heart of Manayunk, one of Philadelphia’s most vibrant and historic neighborhoods. This iconic property is perfectly positioned along bustling Main Street, surrounded by award-winning eateries, boutique retailers, and a thriving residential community. The building features a stunning A-frame skylight that fills the dining area with natural light, complemented by expansive windows and over 55 feet of frontage for exceptional visibility. Inside, operators will find a fully equipped setup with a 20-foot hood and ansul system on the main level and an additional 9-foot hood in the lower-level kitchen, making it ideal for a seamless culinary operation. Outdoor seating potential enhances the guest experience, while proximity to the Manayunk Train Station and major thoroughfares—including I-76, Route 1, and Kelly Drive—ensures easy access for patrons from Center City, the Main Line, and surrounding suburbs. With zoning designated as ICMX, this property is well-suited for a dynamic hospitality concept looking to capitalize on Manayunk’s energetic atmosphere and strong demographics. Whether you envision a trendy bistro, upscale dining, or a neighborhood staple, 4266 Main Street delivers the perfect combination of location, infrastructure, and charm.