422 W 43rd Street offers a rare opportunity to lease a TC-1 (Traditional Commercial) zoned building in Savannah’s Streetcar District, providing exceptional flexibility for a wide range of commercial uses. The property is available for lease at $32/SF NNN and is well suited for restaurant, café, professional office, retail, service-oriented businesses, or short-term vacation rental–compatible uses, subject to applicable city requirements. The ±2,800 SF, two-story building is currently configured in a mixed office/residential layout but is fully zoned for commercial use, allowing an incoming tenant to adapt the space to their operational needs. Architectural features include high ceilings, original character details, and multiple access points that support a variety of single-tenant or creative commercial configurations. The property benefits from a corner location with dual frontage along West 43rd Street and Martin Luther King Jr. Boulevard, providing strong visibility and convenient ingress and egress. A gated rear courtyard and six off-street parking spaces offer a significant advantage in this submarket and enhance functionality for restaurant, office, or client-facing uses. Immediately adjacent to the property is The Jardin, a new mixed-use development by The Rhino Collective currently under construction. The project will introduce additional residential density and ground-floor commercial space, increasing foot traffic and reinforcing the area’s growing appeal for neighborhood-serving businesses. Located just minutes from Downtown Savannah, SCAD housing, and major commuter corridors, the property sits within an active and evolving commercial corridor with strong long-term fundamentals.