410 East 38th Street presents a rare opportunity to acquire a vacant freestanding elevatored building positioned in one of Manhattan’s most strategically influential corridors. Situated just four blocks south of the United Nations and four blocks north of NYU Medical Center, the property sits directly along the city’s renowned Medical Mile, making it uniquely suited for health care, clinical research, diagnostic operations, government missions, or institutional uses. The asset is delivered fully vacant with its interior already demolished, providing a clean slate for immediate redevelopment. Its efficient floorplates, significant frontage, and existing infrastructure offer exceptional flexibility for medical, educational, governmental, or nonprofit operators seeking a custom-built headquarters in a high-demand Midtown East location. Direct adjacency to a parking garage, excellent access to the FDR Drive, and proximity to the Queens–Midtown Tunnel, Queensboro Bridge, and 34th Street Ferry Terminal further enhance operational convenience and patient, student, or staff accessibility. The property benefits from rare tax-exempt eligibility for qualifying nonprofits, 501(c)(3) institutions, hospitals, schools, and government entities. Additionally, buyers may take advantage of the reinstated 100% bonus depreciation, enabling immediate expensing of most capital improvement costs in the first year, substantially reducing taxable income and accelerating investment returns. With its Midtown East positioning, transportation connectivity, and proximity to some of the most significant civic and medical institutions in New York, 410 East 38th Street stands as a compelling opportunity for mission-driven and institutional purchasers seeking long-term presence in a globally recognized district.