3251 Main Street presents a rare mixed-use investment opportunity in the heart of downtown Pikeville, Tennessee. Positioned along the city’s primary corridor and just steps from the Bledsoe County Courthouse, this two-story property combines retail frontage, residential income, and functional specialty space within a single asset. The configuration includes a leased street-facing retail storefront providing immediate cash flow, three fully leased one-bedroom apartments, and a sizeable garage structure with office and full bath offering additional revenue potential through storage, workspace, or future adaptive reuse. An on-site, move-in-ready three-bedroom, two-bath main residence with a private swimming pool elevates flexibility for owner-occupancy or short-term rental strategies. The property’s location blends community engagement and walkability with proximity to regional attractions like Fall Creek Falls and Cumberland State Parks—two major tourism drivers for Eastern Tennessee. With unrestricted use, absence of HOA governance, and inclusion in a designated Opportunity Zone, this asset supports long-term tax-advantaged investment. Multiple income streams, high-visibility frontage, and adaptable physical improvements make this offering attractive for investors, entrepreneurs, and owner-users seeking diversified income and high utility.