Opportunity and versatility define 321 E. 116th Street, a 4-story townhouse with full basement in the heart of East Harlem. Currently configured with a legal Certificate of Occupancy for a two-family residence plus medical office, this property is ideal for both end-users and investors. Create your dream single-family home with expansive living space and modern design, or reimagine the layout into an income-producing multi-family or mixed-use property—the options are endless. With its generous proportions and flexible configuration, this townhouse is a rare canvas ready for transformation. Situated close to vibrant dining, shopping, and cultural destinations, and offering convenient access to multiple subway and bus lines, the location provides the best of city living in a neighborhood that continues to thrive. A true East Harlem opportunity—bring your architect and vision to unlock the full potential of this townhouse.