Top Floor Office Space for Lease – 301 Grand Ave, South San Francisco ±3,689 SF | Prime Downtown Location Position your business at the heart of Downtown South San Francisco with this exceptional top floor office suite. Located on a prominent corner at 301 Grand Avenue, this ±3,689 sq/ft space offers abundant natural light and a flexible layout featuring multiple private offices, conference rooms, and private restrooms. This premier suite is located in a highly walkable, business-friendly neighborhood, surrounded by a vibrant mix of shops, restaurants, and amenities. It includes on-site elevator access, and is ideally positioned with easy access to Highways 101 and 280, just minutes from San Francisco International Airport, and walking distance to Caltrain and other public transit options. Ideal for professional, creative, or medical office use, this centrally located space offers unparalleled convenience and visibility. Contact us today to schedule a tour!