Available Spaces from 500–4,800 SF | Office, Medical, Beauty, Retail & Restaurant Looking for commercial space in Lake City? We have spaces ranging from approximately 500 SF to 4,800 SF, with options to accommodate businesses of all sizes. Located on Marion Avenue (US-441) near downtown and the historic district, these flexible commercial spaces can be configured for a wide variety of businesses, including office, beauty, medical, retail, and restaurant uses. Available Space Options ±500 SF to ±4,800 SF Multiple suite sizes available Flexible layouts and build-out potential High-visibility Marion Avenue location Customer and client parking available Spaces suitable for both established businesses and new startups Larger spaces may offer substantial electrical capacity, including 400-amp, three-phase power Ideal For Office & Professional Services Medical & Healthcare Beauty Salons & Barber Shops Nail, Lash & Esthetics Studios Retail & Specialty Shops Restaurants & Food Service Fitness & Wellness Showrooms Therapy & Chiropractic Insurance, Real Estate, Accounting & Tax Services Location Advantage Located along Marion Avenue (US-441), one of Lake City's primary commercial corridors, with strong visibility and convenient access for both local customers and pass-through traffic. Whether you need a 500 SF startup space or a 4,800 SF location for an established business, we have options to fit your needs.