26 Main Street in Oneonta, NY presents a unique opportunity for investors, developers, or business owners to acquire a prominent mixed-use property with multiple paths for value. Located on Main Street with ±163 feet of frontage, the site benefits from high visibility and a dedicated turning lane for easy ingress and egress. The property sits on ±0.77 acres and includes private parking for approximately 50 vehicles—a rare amenity for downtown. The building totals ±7,754 square feet over two stories, blending historic charm with modern updates, including newer mechanical systems such as a furnace, AC units, and hot water heater. The property currently operates as Alfresco, a well-known restaurant, and offers a buyer the option to continue the existing business, rebrand with a new concept, or reposition the property entirely. Additional features include two on-site residential apartments totaling ±2,300 square feet with three bedrooms and three bathrooms combined, offering an added revenue stream or live-work flexibility. The property is zoned for a wide range of commercial uses, making it ideal for restaurants, breweries, boutique lodging, wellness, offices, or mixed-use redevelopment. Strategically located just off Interstate 88, the site captures both local and regional traffic, with an AADT of 12,008. Oneonta is home to SUNY Oneonta and Hartwick College, contributing a strong student population and consistent year-round demand. The city also benefits from a significant tourism base, driven by national baseball tournaments, Cooperstown All-Star Village events, and other attractions that bring thousands of visitors to the region annually. Whether you’re considering a business takeover, new concept, or full redevelopment, 26 Main Street offers strong fundamentals, strategic location advantages, and a versatile platform for growth.