An exceptional opportunity to acquire a two-building portfolio situated on a combined 0.79 acres in the heart of Holbrook. This rare offering includes a three-bedroom, two-bath legal residential rental home and a 6,910 SF professional/medical office building, formerly the well-known Sachem Animal Hospital. The J2-zoned professional building features multiple entrances, a flexible layout, oil and gas heat, ample on-site parking, strong visibility, and a partial basement with exterior access. The building also includes a freshly painted one-bedroom apartment above, creating an additional income stream or on-site operational convenience. The site benefits from tremendous frontage and a double-sided marquee sign, maximizing exposure for any commercial or medical user. The accompanying three-bedroom, two-bath home is uniquely positioned with mixed J2 and residential zoning, allowing it to function as a legal residential rental or be repurposed for business use, offering exceptional flexibility. The home includes new siding and fresh paint, hardwood and carpet throughout, new Frigidaire appliances, gas heat, a full basement with interior and exterior entrances, a detached one-car garage with ample storage, and a fully fenced yard, enhancing both usability and tenant appeal. The property’s strategic location offers outstanding regional connectivity. It is just minutes from the Station Yards at the Ronkonkoma LIRR and provides easy access to the Long Island Expressway, Sunrise Highway, and other major transportation routes, strengthening both user convenience and long-term investment performance. This portfolio represents an incredible opportunity for an end user, investor, or operator seeking a versatile, well-positioned asset with significant upside potential.