Positioned along highly trafficked US 41 / Tamiami Trail E, 2224 Tamiami Trail E presents a rare opportunity to lease a freestanding 1,750± SF second-generation drive-thru restaurant in the rapidly evolving East Naples corridor. Situated on 0.41± acres with approximately 140’ of frontage, the property offers exceptional visibility, access, and exposure to more than 35,500 vehicles per day nearby. Located between Naples and Marco Island, the site benefits from strong surrounding demographics, growing hospitality activity, and proximity to major developments including JW Marriott Marco Island Beach Resort, The Metropolitan Naples, Avra, and The Halcyon. Zoned C-4, the property is ideally suited for QSR, fast-casual, and drive-thru concepts with existing infrastructure including a drive-thru lane, pylon signage, and ample surface parking.