Prominently located along Newington's main commercial corridor, 2204 Woodbury Avenue offers exceptional visibility and easy access directly adjacent to Route 4, providing seamless connectivity to Portsmouth, the Seacoast, and surrounding markets. This highly accessible location places the property in the heart of Newington's active commercial district. Known as the Isaac Dow House, this iconic building was originally constructed in 1820 and carries a rich and storied history. Once part of the original Dow Farm, the property later evolved into the Fox Point Tavern in the 1970s, followed by the well-known Isaac Dow House Restaurant throughout the 1980s. In 1995, the building transitioned into professional office use, a function it continues to serve today. The property features 2,280+- square feet of office space situated on 0.58 acres within Newington's commercial zone. Recent capital improvements enhance both comfort and efficiency, including a new forced hot water (FHW) heating system installed in July 2025, heat pump heating and cooling, a new roof installed in 2022, and updated plumbing and electrical systems completed in 2021. Reflecting its architectural and cultural importance, the Town of Newington placed a preservation restriction on the property in 1995, limiting certain uses and future development. Combining historic character, modern system upgrades, excellent visibility, and direct Route 4 access, 2204 Woodbury Avenue presents a rare opportunity for businesses seeking a distinctive and well-located office property in the Seacoast region. Subject to seller finding suitable office space. Showings only outside of business hours. After 5PM Monday-Friday or any time on Saturday and Sunday. Please call, email, or text listing office. Listing office must accompany.