Strategically positioned in the midst of vibrant Downtown Roanoke, this two unit 4,400 SF building seamlessly blends historic charm with modern convenience and presents an exceptional opportunity for investors. As Downtown Roanoke is home to more than 900 business and 2600 residents, 22 Campbell Avenue SE is accessible and highly visible. The glass-front first floor is configured as a street-level retail space that includes a half bathroom and is leased to The Market Gallery through March 31, 2030. The second floor has been renovated into an attractive, modern 2bd/2bth residence (2021) and will be available for new occupancy as of February 1, 2026. Recessed lighting, granite and hardwoods throughout, with the potential to develop a rooftop deck. Striking large windows overlook Campbell Avenue and flood the main living area with ambient light. Each spacious bedroom is endowed with an en suite full bathroom, and the primary bedroom with a generous closet. Preferential parking available through PARK Roanoke's Residential Parking Programs. Sum total, 22 Campbell Avenue SE presents a sleek and sophisticated investment prospect for an owner-resident seeking a stable, supplemental income to offset living expenses or for anyone looking to diversify a portfolio. **The building does have a functional sprinkler system. Although currently out of service, there is also an existing freight elevator.