Set in the heart of East Harlem, 2147 2nd Avenue presents a 1,950 square foot, two level retail opportunity positioned to become a true neighborhood destination within one of Manhattan’s most culturally rich and active communities. Located along a vibrant restaurant corridor and situated beneath a mixed use building with 17 residential units, the property benefits from strong visibility, consistent foot traffic, and a built in customer base that supports a wide range of retail and service uses. The space offers a highly efficient and flexible layout, featuring a column free ground floor that spans the full lot depth and width, allowing for maximum usability and customization. This open configuration supports a variety of buildout options, whether for open concept retail, service oriented layouts, or experiential environments. The lower level provides additional usable space and includes pre built showers, making it especially attractive for wellness, fitness, or specialty service operators. Across both levels, the unit includes two bathrooms and is further enhanced by direct rooftop access for rear venting, accommodating uses that require ventilation and expanded operational capabilities. The property is well suited for a wide range of concepts that align with the needs of East Harlem’s diverse and growing population. Potential uses include veterinary clinics, pet care providers, fitness studios, wellness centers, and other service driven businesses that prioritize accessibility and community engagement. Food and beverage concepts such as juice bars, dessert shops, or café style spaces with seating and work areas would also integrate seamlessly into the surrounding restaurant corridor, contributing to the neighborhood’s lively and social atmosphere. With its combination of size, layout flexibility, built in infrastructure, and prime location, 2147 2nd Avenue offers a compelling opportunity for operators seeking to establish a strong and lasting presence in East Harlem. The space supports both functional efficiency and customer experience, making it ideal for businesses looking to grow within a dynamic neighborhood that continues to evolve while maintaining its authentic character.