180 South Boulevard presents a rare opportunity to acquire a single-tenant commercial property in the heart of the San Francisco Peninsula. The offering includes an approximately 1,834-square-foot building situated on a combined approximately 4,767-square-foot site consisting of two parcels. The property's configuration, including a dedicated driveway and access from the front, side, and rear of the building, provides operational flexibility for a variety of commercial uses. Positioned in central San Mateo, the property benefits from exceptional regional connectivity and accessibility. Located just moments from the South El Camino Real corridor, Caltrain, US-101, and State Route 92, the site offers convenient access throughout the Peninsula, Silicon Valley, San Francisco, and the greater Bay Area. This strategic location supports both business operations and customer accessibility while placing the property within one of the region's most established commercial markets. The building's standalone nature provides occupants or future ownership with control over operations, visibility, and site access. The inclusion of two parcels enhances the property's flexibility and contributes to its long-term utility. Its central location places it near a wide range of retail, dining, professional services, and residential neighborhoods that help support ongoing commercial activity within the surrounding area. With a well-located Peninsula address, strong transportation access, flexible site characteristics, and a standalone building configuration, 180 South Boulevard represents an attractive opportunity for investors and owner-users seeking a commercial asset in San Mateo's established business environment.