Located at 1617 E 1st Street in Santa Ana's Lyon Street neighborhood, this two-story, Spanish-style mixed-use building offers a rare combination of ground-floor medical/retail space and second-floor professional office suites within one gated, on-site-parking property. The building has long served as a healthcare and small-business hub, anchored by established tenants including Salud Clinica Medica and JRV Income Tax Svc, and features a mix of turnkey medical, med spa, and general office suites ranging from 500 to 1,500 SF. Situated just east of Downtown Santa Ana's Historic District and minutes from Interstate 5, the Santa Ana Zoo, and the Santa Ana Regional Transportation Center, the property benefits from dense residential surroundings and steady walk-in and drive-to traffic for patient- and client-facing businesses. With an 11' slab-to-slab clear height, full build-outs already in place across multiple suites, and flexible layouts suited to healthcare, wellness, and professional office users, 1617 E 1st Street offers an efficient, move-in-ready opportunity in one of Santa Ana's most established commercial corridors.