Located in Syracuse’s next major growth corridor, 1543 South Salina Street offers 10,400 sq. ft. of versatile commercial space on a prominent 0.65-acre lot. The building includes over 8,600 sq. ft. of high-clearance warehouse, a 1,800 sq. ft. finished office area, seven overhead doors, and a secured fenced yard. With MX-2 zoning and frontage at a signalized intersection, the site is ideally suited for service-based businesses, light industrial operations, logistics, or creative redevelopment. Over 11,000 vehicles pass daily, and three-phase, 480V electric is already in place—providing a true move-in-ready canvas for businesses ready to scale. This property sits at the center of over $1B in public and private investment, including the $400M JMA Wireless tech campus, the $2B I-81 Community Grid project, and the $8.5M ON-RAMP Workforce Hub at the Iconic Sears Building. Located in a federally designated Opportunity Zone and just minutes from Downtown Syracuse, Syracuse University, and Upstate University Hospital, the site offers proximity to major employers, infrastructure improvements, and digital innovation zones. 1543 South Salina is a rare opportunity to capitalize on Syracuse’s next wave of revitalization and position for long-term success.