±17,640 sq. ft. former Rite Aid for lease in Hangtown Village Square. The City of Placerville is centrally located between Sacramento—the State capitol—and South Lake Tahoe, world-famous recreation area. Accessibility to Placerville is via State Highway 49 and U.S. Highway 50, along one of the most traveled corridors in California. Placerville sees significant tourist activity due to its proximity to Highway 50, Lake Tahoe, El Dorado National Forest, El Dorado Wineries, Apple Hill Orchards and Christmas Tree Farms. Placerville is the County seat and the center of financial, commercial, civic and Government activity for El Dorado County.