Zeustra Investment Real Estate Advisors is pleased to present a unique infill investment opportunity at 1123 N Main Avenue, a high-character, two-story medical office building located in the heart of San Antonio’s rapidly transforming urban core.
Just blocks from Methodist Hospital and Baptist Medical Center, and surrounded by more than $1 billion in nearby planned and ongoing development, this ±37,708 SF asset offers immediate functionality and significant long-term upside in one of Texas’s most active healthcare and redevelopment corridors.
The building sits on ±1.10 acres with 131 on-site parking spaces—a rare urban amenity—and is configured for clinical/medical use. It was extensively remodeled in 2004 and further upgraded in 2016, with C-3 zoning allowing for a wide range of medical, office, or mixed-use strategies. Its mostly vacant status allows for immediate activation with no legacy lease constraints.
Positioned within San Antonio’s Tobin Hill/Pearl District, 1123 N Main is steps from the $446 million VIA Rapid Transit Green Line, and within close proximity to major urban projects including the $160M Missions Ballpark Redevelopment, $300M Museum Reach Mixed-Use Project, and the proposed $1B San Antonio Spurs Downtown Arena and Entertainment District.
With a prime location, zoning flexibility, and direct access to infrastructure, hospitals, and institutional investment, this property represents a rare blank canvas—ideal for re-tenanting, adaptive reuse, or ground-up redevelopment in a high-growth submarket.