110 Defense Highway presents a mixed-use investment or owner-user opportunity in Annapolis, Maryland. The property includes office and retail space along with a second-floor apartment, creating flexibility for a variety of business and occupancy strategies. Positioned along Defense Highway, the asset benefits from strong visibility and convenient access within one of the region's established commercial corridors. The property's configuration supports a range of potential uses, while its C2 zoning designation provides additional operational flexibility. Two curb cuts allow for efficient ingress and egress, enhancing accessibility for customers, employees, and residents. Abundant on-site parking further supports daily operations and visitor convenience. An additional detached two-car garage/storage building provides supplementary storage or support space, adding functional utility to the property. Its location offers connectivity to major regional destinations, including Washington, D.C., Baltimore, and Baltimore/Washington International Airport, making it well positioned for businesses seeking access to the broader Central Maryland market. The combination of mixed-use functionality, visibility, parking, and regional accessibility creates a compelling opportunity for investors, owner-users, or businesses seeking a property with multiple occupancy and operational options in the Annapolis area.