101 San Marco Dr, Venice, FL 34285 is a freestanding 2,917 SF professional office building zoned OPI (Office/Professional/Institutional), ideally positioned one block west of US-41/Tamiami Trail in a high-visibility Venice Island corridor. The single-story property supports flexible office layouts for medical, professional, or institutional tenants, with ample surface parking, convenient drive-up access, and a practical design suited to the walkable downtown area near shops, dining, and the beach. Built in the mid-to-late 20th century with updates for modern office use, the building offers strong connectivity via Tamiami Trail/US-41 to I-75 (3 miles north), Venice Avenue, and the broader Gulf Coast network linking Sarasota (15 minutes north) and Englewood (10 minutes south). Amenities include on-site parking (sufficient for small office users), zoning flexibility for a wide range of professional services, and proximity to Venice Regional Hospital, making it a turnkey location in one of Venice's most desirable commercial nodes.