101 E 25th Avenue presents a rare opportunity to acquire a highly functional office/flex property in the heart of San Mateo. Situated on a prominent corner parcel at 25th and Palm Avenue, this asset combines convenience, visibility, and versatility for a wide range of business uses. The property features approximately 3,850 square feet of renovated office and warehouse/storage space, including a detached unit equipped with a restroom, shower, and employee lockers—ideal for operations requiring both administrative and light industrial capabilities. The ±11,500-square-foot lot offers secure, gated parking for approximately 23 vehicles, ensuring ease of access and safety for staff and visitors. Building signage is available, providing excellent branding potential along a well-traveled corridor. Zoned C1-2 Neighborhood Commercial, the site supports a variety of commercial uses, making it an attractive option for owner-users or investors seeking a strategic foothold in a thriving Peninsula market.