This versatile building offers a unique leasing opportunity in the Brightleaf District of downtown Durham, just ±0.25 miles from Duke University with seamless access to the Durham Freeway. This highly visible, well-maintained, and locally owned building features an expansive, contiguous layout with high ceilings—offering flexible space well-suited for a range of commercial uses. While some interior upfitting may be needed for more polished operations, the building provides solid functionality and adaptability in a prime downtown location. The property is in the Central Business District, zoned DD-S1 (Downtown Design – Support 1), a flexible zoning district intended to support a mix of commercial, office, institutional, and residential uses in a walkable urban environment. A wide range of uses are permitted by right, including retail, office, flex, creative studio, gallery, fitness, personal services, education, medical, recreation, restaurant, and research & development. Light industrial and small-scale production uses may also be allowed, provided they are compatible with the surrounding urban context. 1010 W Main St offers unmatched access and visibility in one of the region’s most vibrant urban corridors. Surrounded by a blend of historic and modern developments, the building sits across from Brightleaf Square and is walkable to major downtown landmarks like Durham Central Park, DPAC, the American Tobacco Campus, and Duke’s East Campus. The Durham Freeway is less than two minutes away—offering seamless connectivity to RTP, Chapel Hill, and Raleigh. The layout includes a contiguous 4,623 SF street-facing retail storefront, 5,808 SF of office space on the upper floors, and a fully conditioned 5,170 SF warehouse with two drive-in doors. Ceiling heights range from 13’ to 17’, and the entire building is climate-controlled. A rare amenity in downtown, the property offers ±31 surface parking spaces on-site. Whether you're seeking a dynamic headquarters, destination retail, or a flexible hybrid space, 1010 W Main offers the visibility, location, and infrastructure to bring your vision to life.